Therapeutic targeting of HES1 transcriptional programs in T-ALL

Therapeutic targeting of HES1 transcriptional programs in T-ALL.

Oncogenic activation of NOTCH1 signaling plays a central role in the pathogenesis of T-cell acute lymphoblastic leukemia, with mutations on this signaling pathway affecting more than 60% of patients at diagnosis. However, the transcriptional regulatory circuitries driving T-cell transformation downstream of NOTCH1 remain incompletely understood. Here we identify Hairy and Enhancer of Split 1 (H...

Therapeutic Targeting of c-Myc in T-Cell Acute Lymphoblastic Leukemia (T-ALL)

T-ALL patients treated with intensive chemotherapy achieve high rates of remission. However, frequent long-term toxicities and relapses into chemotherapy-refractory tumors constitute major clinical challenges which could be met by targeted therapies. c-MYC is a central oncogene in T-ALL, prompting the exploration of the efficacy of MYC inhibitors such as JQ1 (BET-bromodomain inhibitor), and SAH...

Targeting Transcriptional Dysregulation in Huntington’s Disease: Description of Therapeutic Approaches

Targeting aberrant transcriptional repression in leukemia: a therapeutic reality?

The discovery that transcription factors are frequently disrupted in leukemia has led to efforts to target these proteins with drugs. These efforts have met with limited success, partly because it has proved difficult to design and deliver into the nucleus small molecules that might break up interactions between transcription factors and their target genes or cofactors. Hence the belief that tr...

Community based prevention programs targeting all injuries for children.

OBJECTIVE Community based models for injury prevention have become an accepted part of the overall injury control strategy. This systematic review of the scientific literature examines the evidence for their effectiveness in reducing all-cause injury in children 0-14 years of age. METHODS A comprehensive search of the literature was performed using the following study selection criteria: comm...